BREAKING Liam Payne, former One Direction member, dies at 31 in Argentina hotel fall
Former One Direction singer Liam Payne, 31, was found dead after falling from a hotel balcony in Buenos Aires on Wednesday, local officials said.
Adding a six-week course of chemotherapy to the standard course of treatment for locally advanced cervical cancer resulted in a significant increase in survival rates, .
The study, published Monday in the journal The Lancet, involved 500 patients from 32 medical centres in Brazil, India, Italy, Mexico and the UK who were randomly assigned into two groups between 2012 and 2022. All had locally advanced cervical cancer, although none had tumours that had spread to other organs.
The control group received only chemoradiotherapy, a standard process that included treatment with radiation and the drug cisplatin. The experimental group received six weeks of treatment with carboplatin and paclitaxel chemotherapy before beginning chemoradiotherapy.
The researchers found that 80 per cent of those who got a short course of chemotherapy first lived at least five more years, and 72 per cent did not have any cancer return or spread. In the control group, 72 per cent survived at least five years, and 64 per cent had no cancer return or spread.
Most patients had some kind of adverse event during treatment, including fatigue or weakness, gastrointestinal problems, infections or low white blood cell counts. Severe or life-threatening events happened in 59 per cent of the group that got initial chemotherapy, compared with 48 per cent of those who got chemoradiotherapy alone.
The researchers say theirs is the first randomized phase three study to show a "significant survival advantage" using chemotherapy before chemoradiotherapy, representing a "clinically meaningful improvement" at a "relatively low cost." The drugs are cheap and widely available, they say.
"This is the biggest improvement in outcome in this disease in over 20 years," Dr. Mary McCormack of University College Hospital, lead author of the study, said in an interview with . "I'm incredibly proud of all the patients who participated in the trial; their contribution has allowed us to gather the evidence needed to improve treatment of cervical cancer patients everywhere."
Cisplatin-based chemotherapy is one of the most commonly used methods of treating cervical cancer, by 30 per cent to 50 per cent. While tumour removal surgery is an option, some experts tend to prefer chemotherapy.
"We know that surgery is going to leave some of the cancer behind," said Dr. Otis Brawley, a professor of oncology at Johns Hopkins University and former chief medical officer of the American Cancer Society, who was not involved with the new research. "If you can treat with radiation and chemotherapy, you have a chance that you're going to sterilize the pelvis of all of the cancer. 鈥 We have the chances that we're going to put women into a prolonged, complete remission."
Cervical cancer was once the leading cause of cancer death for women in the United States, he noted. In 2008, Harald zur Hausen, a German virologist, won the Nobel Prize for his research demonstrating that cervical cancer in humans is caused by certain types of human papillomavirus, or HPV. This discovery led to the development of an HPV vaccine that can help prevent cervical cancer in women.
However, cervical cancer still kills about in the U.S. each year. Warning signs include abnormal bleeding or discharge.
Brawley stressed the importance of routine cervical screening as advanced-stage cervical cancer rises among in the U.S.
According to the U.S. Centers for Disease Control and Prevention, cervical cancer screenings typically test for signs of HPV that can cause cell changes on the cervix. The screenings also include a Pap test to look for precancer cell changes.
The U.S. Food and Drug Administration greenlit a this year for patients to collect their own vaginal samples to test for HPV, streamlining the screening process.
"It's almost totally preventable with either the HPV vaccine or screening," Brawley said. "Of the 4,400 deaths from cervical cancer, none of them get screened every year."
Chemotherapy to treat cervical cancer can come with unpleasant side effects like nausea, vomiting and hair loss, Brawley noted. He hopes the future of treatment will involve more personalized options like immunotherapy, which uses a person's own immune system to fight cancer.
"The greatest hope is immunotherapy," he said. "We're hoping we can actually help even more women with less side effects."
Former One Direction singer Liam Payne, 31, was found dead after falling from a hotel balcony in Buenos Aires on Wednesday, local officials said.
Liberal MPs who have spent the last 10 days organizing to ask Prime Minister Justin Trudeau to step aside from the leadership of the Liberal Party plan to plead their case directly to him at next Wednesday's caucus.
The OPP has acknowledged that one of its employees did not follow the organization's policy when an alleged victim of sexual assault called a local detachment earlier this year to report an incident involving eight former junior hockey players.
Mounties have released startling new details about their investigation into the disappearance of Amber Manthorne, who was reported missing on Vancouver Island more than two years ago, and is believed to have met with foul play.
The Canada Revenue Agency says it has terminated 330 employees for inappropriately receiving the Canada Emergency Response Benefit during the pandemic, giving its final update on an internal review.
Conservative Leader Pierre Poilievre has refused to get the security clearance necessary to be briefed on a list of people in his party who are involved in or vulnerable to foreign interference, Prime Minister Justin Trudeau told a federal commission of inquiry Wednesday.
Health Canada released an advisory Wednesday warning that baby walkers available online may pose a risk of injury and reminding consumers the items are already banned in Canada.
A Nevada boy with a rare skin condition had life-changing eyelid and skin graft surgery last month in San Diego.
Republican U.S. presidential candidate Donald Trump says that if he does not win the Nov. 5 election, he will cry fraud and not accept the results -- just as he did four years ago when he lost to Democratic President Joe Biden.
An Ottawa man was arrested after taking a shower in a stranger's house, Ottawa police say.
S岣祑x瘫w煤7mesh 脷xwumixw (Squamish Nation) Chef Paul Natrall, the man behind Indigenous food truck Mr. Bannock, is bringing cooking classes on First Nations fare to schools and offices throughout Metro Vancouver.
The Celtic Colours Festival is taking place at venues around Cape Breton Island in Nova Scotia from Oct. 11 to 19.
Sometimes love is written in the stars, but for one couple, it鈥檚 written in the aurora borealis.
Canadian hip hop artist Dillan King says running 100 marathons in 100 days was not only the hardest thing he has ever done, but the 'proudest accomplishment' of his entire life.
James Taylor never expected to be walking home with a bag full of groceries he didn't buy.
This weekend marks the fifth anniversary of a large blizzard that paralyzed Manitoba.
There was an eye-catching mix of rainbows and lightning over Vancouver following a brief downpour this week.
Jeff Warner from Aidie Creek Gardens in the northern Ontario community of Englehart has a passion for growing big pumpkins and his effort is paying off in more ways than one.