Eli Lilly's blockbuster diabetes drug Mounjaro and weight-loss therapy Zepbound, as well as Novo Nordisk's rival medicines Ozempic and Wegovy, are being studied to see whether they can improve health in other ways.
The U.S. Food and Drug Administration on Friday Novo's Wegovy for lowering the risk of stroke and heart attack in overweight or obese adults who do not have diabetes.
Below are other conditions obesity treatments are being tested against:
Alcohol addiction
A study by the University of Copenhagen's Psychiatric Centre Rigshospitalet is investigating whether semaglutide, sold as Novo's Wegovy and Ozempic, can help reduce alcohol intake in diagnosed with alcohol use disorder and obesity.
Alzheimer's disease
Novo Nordisk has begun a testing semaglutide in patients with early Alzheimer's disease. The study, which will enrol 1,840 patients, could reach primary completion as early as 2025.
Cardiovascular disease
Eli Lilly is testing tirzepatide, sold as Mounjaro and Zepbound, for patients and obesity. Lilly plans to enrol about 700 people in the study, which is expected to be completed by July 2024.
Researchers at the Chinese University of Hong Kong are testing Novo's semaglutide along with the mechanical removal of clots in patients with strokes caused by the blockage of large blood vessels to the brain. The approach will be compared with standard therapy. The mid-stage aims to recruit about 140 patients.
Chronic kidney disease
Novo's Ozempic delayed the progression of chronic kidney disease in diabetes patients, cutting the risk of death from that and major cardiac events by 24%. That was, however, below investor expectations.
Lilly's tirzepatide is being evaluated in a of chronic kidney disease in patients with obesity. Lilly plans to enrol up to 140 participants.
Liver disease
Novo is testing semaglutide in a late-stage trial of patients with a common type of fatty liver disease called non-alcoholic steatohepatitis (NASH). The is expected to enroll about 1,200 patients.
helped up to 74% of patients achieve absence of the disease with no worsening of liver scarring at 52 weeks, compared with 13% of patients on placebo, in a mid-stage trial for the fatty liver disease formerly known as NASH and now called metabolic dysfunction-associated steatohepatitis, or MASH.
Neurological disorders
Researchers at the Danish Headache Centre are testing semaglutide along with a very low-calorie diet as a treatment for new-onset idiopathic intracranial hypertension, a condition associated with obesity in which blood pressure inside the head rises. The aims to recruit about 50 patients and wrap up as early as 2025.
Sleep apnea
Lilly's tirzepatide is in for patients with obstructive sleep apnea and obesity, including people who use respiratory devices that help keep their airways open while they sleep, as well as people who don't use such devices. The study is expected to enrol about 469 participants.
(Reporting by Patrick Wingrove in New York and Sriparna Roy in Bengaluru. Editing by Bill Berkrot and Devika Syamnath)
