Pfizer has begun a study comparing its original COVID-19 vaccine with doses specially tweaked to match the hugely contagious Omicron variant.
on Tuesday.
COVID-19 vaccine-makers have been updating their shots to better match Omicron in case global health authorities decide the change is needed.
Omicron is more likely than previous variants to cause infection even in people who've been vaccinated, but it's not yet clear that a change to the vaccine recipe will be ordered. Among the issues regulators are weighing: Some of the first places to face an Omicron surge already are seeing the mutant wane -- and there's no way to know if the next variant that arises will resemble Omicron or be totally different.
The original vaccines still offer good protection against severe illness and death. Studies in the U.S. and elsewhere have made clear that adding a booster dose strengthens that protection and improves the chances of avoiding a milder infection.
"We recognize the need to be prepared in the event this protection wanes over time and to potentially help address omicron and new variants in the future," Kathrin Jansen, Pfizer's vaccine research chief, said in a statement.
The new U.S. study is enrolling up to 1,420 healthy adults, ages 18 to 55, to test the updated Omicron-based shots for use as a booster or for primary vaccinations. Researchers will examine the tweaked vaccine's safety and how it revs up the immune system in comparison to the original shots.
Full study results will take many months as volunteers receive multiple vaccine doses -- and as researchers measure how long virus-fighting antibodies remain at high levels after an omicron-adapted dose versus the regular booster.
Pfizer's CEO told CNBC earlier this month that the company could have some Omicron-matched doses ready as early as March. But doing what the company calls "at-risk" manufacturing doesn't mean those doses will be rolled out to the public. Pfizer and other vaccine makers also have brewed and tested experimental doses to match previous variants, changes that ultimately weren't needed but offered valuable practice at tweaking the recipe.
For the new study, one group of about 600 volunteers who received two doses of the current Pfizer vaccine three to six months ago will receive either one or two Omicron-based shots as boosters. Another 600 who've already gotten three regular doses of the Pfizer vaccine will be given a fourth dose of either the regular vaccine or the Omicron-matched version.
The study also will enroll some unvaccinated volunteers who will receive three doses of the Omicron-based vaccine.
Pfizer plans to produce 4 billion vaccine doses in 2022, and said Tuesday the amount isn't expected to change if an Omicron-adapted version is needed.
------
The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute's Department of Science Education. The AP is solely responsible for all content
A new round of airstrikes hit Beirut suburbs late Sunday as Israel intensified its bombardment of northern Gaza and southern Lebanon in a widening war with Iran-allied militant groups across the region. Palestinian officials said a strike on a mosque in Gaza killed at least 19 people.
A unique form of clouds made an appearance over the skies of Ottawa on Sunday evening.
'Eat more vegetables,' doctors and dietitians say over and over. But for many people, it’s hard to do, because they aren’t excited about veggies or just don’t like them.
People across Florida were given notice Sunday that Hurricane Milton is intensifying rapidly and will likely be a major hurricane before slamming midweek into the storm-ravaged Gulf Coast.
Weeneebayko Area Health Authority and the Government of Ontario have awarded a $1.8 billion fixed-price contract to design, build and finance a new Far North hospital.
The people of Fort Chipewyan believe the federal government knew its water was contaminated and hid the issue for years. Now the chief of the Athabasca Chipewyan First Nation is leading the call for immediate action.
Christopher Ciccone, a multihyphenate artist, dancer, designer and younger brother of Madonna, has died. He was 63.
New data raises questions about the drinks people consume and the potential risks associated with them, according to researchers at Galway University in Ireland, in partnership with Hamilton’s McMaster University.
As a junior at George Washington University, Ty Lindia meets new students every day. But with the shadow of the Israel-Hamas war hanging over the Washington, D.C., campus, where everyone has a political opinion, each new encounter is fraught.
A 54-year-old inmate at the Toronto South Detention Centre has been charged in connection with a deadly jail beating late last week that claimed the life of a 69-year-old prisoner.
The Archbishop of Toronto is among 21 new cardinals Pope Francis named Sunday and the lone new cardinal from North America.
A unique form of clouds made an appearance over the skies of Ottawa on Sunday evening.
In a display of strength and perseverance, a Cambridge, Ont. resident has completed a unique aquatic challenge.
Some Manitobans are cleaning up Sunday morning, after intense winds barreled through southern parts of the province Saturday.
A gargantuan gourd – affectionately named ‘Orangina’ by the urban gardeners who grew it in the front yard of their Vancouver home – earned the massive honour of being named B.C.’s heaviest giant pumpkin Saturday.
A new round of airstrikes hit Beirut suburbs late Sunday as Israel intensified its bombardment of northern Gaza and southern Lebanon in a widening war with Iran-allied militant groups across the region. Palestinian officials said a strike on a mosque in Gaza killed at least 19 people.
Advocacy groups behind a so-called suicide capsule said Sunday they have suspended the process of taking applications to use it as a criminal investigation into its first use in Switzerland is completed.
Donald Trump's fourth scheduled stop in eight days in Wisconsin is a sign of his increased attention as Republicans fret about the former president's ability to match the Democrats' enthusiasm and turnout machine.
British Prime Minister Keir Starmer's chief of staff quit on Sunday, citing concerns that growing news reports about her role 'risked becoming a distraction to the government.'
As a junior at George Washington University, Ty Lindia meets new students every day. But with the shadow of the Israel-Hamas war hanging over the Washington, D.C., campus, where everyone has a political opinion, each new encounter is fraught.
It was a year ago when Jomana Siddiqui visited Lebanon, where her father was born — and is now buried. She planned to return there soon; this time, she thought, she would take her two teenage daughters.
Justin Trudeau will travel to Laos later this week for the ASEAN summit, marking what his office says will be the first official visit of a Canadian prime minister to the Southeast Asian country.
In an interview with CTV’s Question Period host Vassy Kapelos, airing Sunday, Cohen said that despite the failed attempt at a pause, he still believes a ceasefire is possible.
On Saturday, tensions rose again between Quebec and Ottawa at the Coalition Avenir Québec (CAQ) political conference in Saint-Hyacinthe.
Rwandan health authorities will begin a vaccine study against the Marburg hemorrhagic fever, officials said Sunday, as the East African country tries to stop the spread of an outbreak that has killed 12 people.
Bruzzese came down with COVID-19 in February 2023, and received her injection at the end of March. “Being able to recognize smells is something we take for granted, until you can’t.â€
New data raises questions about the drinks people consume and the potential risks associated with them, according to researchers at Galway University in Ireland, in partnership with Hamilton’s McMaster University.
Scientists announced on Thursday a milestone in neurobiological research with the mapping of the entire brain of an adult fruit fly, a feat that may provide insight into brains across the animal kingdom, including people.
For humans, flashing a smile is an easy way to avoid misunderstanding. And, according to a new study, bottlenose dolphins may use a similar tactic while playing with each other.
Alphabet's Google is testing showing check marks next to certain companies on its search results, a company spokesperson said on Friday, in a move aimed at helping users identify verified sources and steer clear of fake websites.
Christopher Ciccone, a multihyphenate artist, dancer, designer and younger brother of Madonna, has died. He was 63.
Donald Glover has cancelled the remaining dates of Childish Gambino’s North American and European tour.
'Joker: Folie a Deux' is the No. 1 movie at the box office, but it might not be destined for a happy ending.
Financial strain can be an uncomfortable burden to bear, especially if you feel that you're doing as much as you can and are barely managing to stay afloat. Personal finance contributor Christopher Liew shares some tips for managing financial stress and digging your way out of debt.
Yugali Bharote starts her day in the kitchen, preparing lunch boxes for her sons bound for school – but she doesn’t stop there. She then prepares almost a dozen lunch boxes for customers who have subscribed to her homemade meals.
Dubai's Emirates airline has banned pagers and walkie-talkies from its planes, following last month's attacks on such devices carried by the Lebanese militant group Hezbollah.
'Eat more vegetables,' doctors and dietitians say over and over. But for many people, it’s hard to do, because they aren’t excited about veggies or just don’t like them.
Travelling on a budget can be stressful, but there are ways you can ensure you're getting the best deal on flights as the holiday season approaches.
A five-seat sushi counter located inside another restaurant is the latest Vancouver eatery to receive a Michelin star.
The Carleton Ravens came within a field goal of their first Panda Game victory since 2017, but ultimately came short of breaking the University of Ottawa Gee Gees winning streak on Sunday.
Of the 32 NHL head coaches standing behind benches at the start of last season, 12 are no longer in the same role — including the retired Rick Bowness.
Vanderbilt takes down AP poll No. 1 Alabama 40-35 in historic college football victory.
New data from the Insurance Bureau of Canada (IBC) shows that even though claims for auto theft dropped in the first half of 2024 compared to their 2023 peak, the rates of reported theft remain well above those of years prior.
Tesla is recalling more than 27,000 Cybertrucks because the rearview camera image may not activate immediately after shifting into reverse, the fifth recall for the vehicle since it went on sale late last year.
A Pickering, Ont., student going to college to be a mechanic is shocked the engine in his two-year-old car will not be repaired under warranty after the dealership claimed he had been 'over-revving' the engine.
Bernie Hicks, known as the ‘Batman of Amherst,’ always wanted to sit in a Batmobile until a kind stranger made it happen.
Bubi’s Awesome Eats, located on University Ave West took to social media to announce the closure on Friday.
Weeneebayko Area Health Authority and the Government of Ontario have awarded a $1.8 billion fixed-price contract to design, build and finance a new Far North hospital.
Some Manitobans are cleaning up Sunday morning, after intense winds barreled through southern parts of the province Saturday.
Avry Wortman, 13, scored two touchdowns on Sunday during her team's win in the under 14 Greater Moncton Football Association.
A gargantuan gourd – affectionately named ‘Orangina’ by the urban gardeners who grew it in the front yard of their Vancouver home – earned the massive honour of being named B.C.’s heaviest giant pumpkin Saturday.
Chantal Kreviazuk is set to return to Winnipeg to mark a major milestone in her illustrious musical career.
From the beaches of Cannes to the bustling streets of New York City, a new film by a trio of Manitoba directors has toured the international film festival circuit to much pomp and circumstance.
A husband and wife have been on the road trip of a lifetime and have decided to stop in Saskatchewan for the winter.
One person was killed and four others hospitalized when a car sped off the road and rolled over south of Merritt, B.C., Saturday, according to authorities.
One person is dead after the driver of a pickup truck hit a bench where two people were waiting for the bus in Surrey Saturday afternoon, police have confirmed.
The calculus of predicting an election and identifying its key battlegrounds is complex enough in any race, but observers of the British Columbia poll this month are facing a pair of unknown quantities that make the math even more confounding.
A 54-year-old inmate at the Toronto South Detention Centre has been charged in connection with a deadly jail beating late last week that claimed the life of a 69-year-old prisoner.
The Archbishop of Toronto is among 21 new cardinals Pope Francis named Sunday and the lone new cardinal from North America.
A female has been taken to the hospital after being stabbed early Sunday afternoon in Oakville, say police.
CTV producer Cynthia Roebuck has been to the Run for a Cure before, but Sunday, she had a different perspective on the popular event.
An investigation is underway after a collision that took place on Deerfoot Trail early Saturday evening.
An investigation is underway into a fire and explosion that took place Saturday night in northeast Calgary.
A unique form of clouds made an appearance over the skies of Ottawa on Sunday evening.
The Carleton Ravens came within a field goal of their first Panda Game victory since 2017, but ultimately came short of breaking the University of Ottawa Gee Gees winning streak on Sunday.
Ontario Provincial Police say a man has died after striking obstacles on the St. Lawrence River while driving a personal watercraft.
Alexandre Look, a 33-year-old Montreal native, was among the concertgoers who were murdered a year ago Monday at the Supernova music festival during a brutal assault on Israel carried out by Hamas militants. He is among at least eight people, either Canadian citizens or with ties to Canada, who died during the Oct. 7 attacks.
Monday marks one year since the Hamas attack that killed 1,200 Israelis and triggered the ongoing war in Gaza.
A man was taken into custody Sunday after a woman was found dead in a home on Montreal's South Shore.
If you're feeling overwhelmed by an overbearing fruit tree or a kale patch that just won't quit, here are some ways to make your fall haul more manageable.
According to a survey on recent alcohol consumption, younger Canadians are more likely to have not had a drink in the past week. For those interested in slowing or stopping their alcohol consumption, there's a phrase: 'sober curious.'
Of the 32 NHL head coaches standing behind benches at the start of last season, 12 are no longer in the same role — including the retired Rick Bowness.
Bernie Hicks, known as the ‘Batman of Amherst,’ always wanted to sit in a Batmobile until a kind stranger made it happen.
RCMP in Sussex, N.B., are asking the public for help locating a missing 61-year-old woman from Wards Creek, N.B.
The eight sons of Richard and Sarah Harvie from Gormanville, N.S., are believed to be the most siblings from one family, from either North America or the British Commonwealth, to serve in World War II.
Some Manitobans are cleaning up Sunday morning, after intense winds barreled through southern parts of the province Saturday.
An annual vintage sale known as “Art from the Attic†returned to St. Vital Centre Sunday, with thousands of collectibles and art pieces on display.
For the 52nd week, pro-Palestinian protesters rallied in Winnipeg, calling for peace in the Middle East amid the ongoing Israel-Hamas war.
Saturday was not an ideal fall day for the residents of southern Saskatchewan – as winds reaching highway speeds were reported.
The Saskatchewan Roughriders have clinched a playoff spot thanks to a win over the Edmonton Elks.
Saskatchewan's two major political parties made campaign stops in Moose Jaw Saturday with both promising to invest into the city if elected on Oct. 28.
According to police, officers responded to reports of a stabbing in the area of Victoria Street North and St. Ledger Street around 5:30 a.m. Sunday.
In a display of strength and perseverance, a Cambridge, Ont. resident has completed a unique aquatic challenge.
Emergency services were called to the area of Stone Road West and Chancellors Way around 1:20 a.m. Sunday for a report of a single motor vehicle collision.
The Saskatchewan Roughriders have clinched a playoff spot thanks to a win over the Edmonton Elks.
The Saskatchewan Teachers' Federation hosted a virtual election forum on education Thursday evening, giving candidates in the provincial election a chance to share their thoughts and answer questions on issues teachers find most important.
Saturday was not an ideal fall day for the residents of southern Saskatchewan – as winds reaching highway speeds were reported.
Weeneebayko Area Health Authority and the Government of Ontario have awarded a $1.8 billion fixed-price contract to design, build and finance a new Far North hospital.
According to a survey on recent alcohol consumption, younger Canadians are more likely to have not had a drink in the past week. For those interested in slowing or stopping their alcohol consumption, there's a phrase: 'sober curious.'
Hundreds of people are gathering today in cities across Canada to remember the victims of Hamas's Oct. 7 attack on Israel and the hostages that have still not yet made it home.
Tears were shed and emotions ran high at the 33rd annual CIBC Run for the Cure in downtown London, Ont. on Sunday.
The London Knights continue to get players back from NHL training camps but while the roster takes shape, wins have been tough to come by in the early season.
People across Florida were given notice Sunday that Hurricane Milton is intensifying rapidly and will likely be a major hurricane before slamming midweek into the storm-ravaged Gulf Coast.
The first Sunday of October was also the first Sunday of Breast Cancer Awareness Month, which meant hundreds wore pink and attended the two CIBC 'Run for the Cure' events in the region.
Police in Barrie allegedly seized a semi-automatic pistol and drugs during an overnight investigation that resulted in the arrest of three men downtown.
Lakehead University's Orillia Campus hosted the 2024 NASA Space Apps challenge this weekend, which allowed teams of students, mentors and scientists to brainstorm solutions for global issues using real-world NASA data.
This morning just before 7:00 a.m., OPP responded to a collision in which a vehicle struck a pedestrian on the roadway.
The event serves as a pivotal platform for open-class boxers from across Ontario to compete for provincial titles and the opportunity to advance to the Canadian National Championships.
Bubi’s Awesome Eats, located on University Ave West took to social media to announce the closure on Friday.
The calculus of predicting an election and identifying its key battlegrounds is complex enough in any race, but observers of the British Columbia poll this month are facing a pair of unknown quantities that make the math even more confounding.
Police on Vancouver Island have made an arrest in the case of a 78-year-old woman found dead in her home almost two years ago.
NDP Leader David Eby is promising to offer a $75-million loan forgiveness program to entice doctors, nurses and heath professionals to expand health-care services in rural British Columbia.
Nearly two years after a man was stabbed to death in downtown Kelowna, RCMP have made an arrest in the case.
NDP Leader David Eby is promising to offer a $75-million loan forgiveness program to entice doctors, nurses and heath professionals to expand health-care services in rural British Columbia.
Three young suspects have been arrested in connection with a swarming attack on a teenager in B.C.'s Okanagan last week – and authorities have asked the public to stop circulating disturbing videos of the incident.
While the summer may be over, construction season in Lethbridge is not.
Lethbridge police executed dozens of warrants and laid numerous charges in another targeted enforcement project in the downtown area.
A person was airlifted to hospital following a serious crash in Taber, Alta., on Friday morning. Taber RCMP responded to the scene on Highway 864 around 10:30 a.m., for a crash involving an SUV and a semi-truck.
As part of an ongoing investigation, provincial police are seeking the public’s assistance in locating a Kubota tractor stolen in North Shore Township, Ont., last month.
A 33-year-old man was arrested Saturday for allegedly spraying bear mace at three individuals in northwestern Ontario.
A drug raid on a home on the Far North Attawapiskat First Nation last week resulted in two local residents being charged and more than $50,000 in suspected narcotics, including methamphetamine, being seized.
He may not have logged the fastest time or even gone the full distance, but residents of a Newfoundland town agree the goat who unexpectedly joined the local weekend half marathon was the event's undisputed champion.
A mother in a community where the cost of living is one of the highest in the country says grocery prices are 'inhumane' and retailers are putting profits ahead of people’s basic human right to food.
A soccer game in England on Tuesday night drove a spike in online traffic across the Atlantic to a website launched by the Newfoundland and Labrador government.
The Shopping Trends team is independent of the journalists at Â鶹´«Ã½. We may earn a commission when you use our links to shop. Read about us.
