Trial data from AstraZeneca on Friday raised the prospect of a new treatment to prevent COVID-19 beyond vaccines, giving hope in particular for people who respond poorly to immunization shots.
reduced the risk of people developing any COVID-19 symptoms by 77 per cent in a late-stage trial.
While vaccines rely on an intact immune system to develop an arsenal of targeted antibodies and infection-fighting cells, AstraZeneca's AZD7442 therapy consists of lab-made antibodies that are designed to linger in the body for months to stifle the coronavirus in case of an infection.
The company said that 75 per cent of the participants in the trial for the therapy - which comprises two types of antibodies discovered by Vanderbilt University Medical Center in the United States - had chronic conditions including some with a lower immune response to vaccinations.
Similar therapies made with a drug class called monoclonal antibodies are being developed by Regeneron, Eli Lilly and GlaxoSmithKline with partner Vir, competing for a role in COVID treatment and prevention.
But AstraZeneca is first to publish positive prevention trial data in the field and is now targeting conditional approval in major markets well before the end of the year, aiming to produce roughly 1 to 2 million doses by then.
Penny Ward, Visiting Professor in Pharmaceutical Medicine at Kings College in London, said the news bode well for people who have responded poorly to vaccination or who must take immune-suppressants for post-transplant, autoimmune disease and other conditions.
"It could potentially be game changing for these individuals, who are currently being advised to continue to shield despite being fully vaccinated," she said.
The good news on the therapy was tempered, however, by a separate AstraZeneca statement on Friday.
It said a trial of a treatment for the rare neurological disorder amyotrophic lateral sclerosis (ALS), developed by AstraZeneca's newly acquired Alexion, had been stopped early due to a lack of efficacy.
AstraZeneca shares were up just 0.1 per cent at 1400 GMT.
AstraZeneca executive Mene Pangalos said the therapy trial results were taken three months after the antibodies were injected and investigators would follow up as far out as 15 months in the hope the company can tout the shot as a year-long shield.
"We’re really trying to help patients that need an added level of protection on top of a vaccine," said Pangalos.
He signaled that the prospects of a new COVID-19 product in AstraZeneca's medicine cabinet could also enhance the strategic value of its existing vaccine Vaxzevria, which it developed in collaboration with Britain's Oxford University.
"No other company has delivered two molecules against SARS-CoV2. This definitely helps us in positioning us in terms of COVID," Pangalos told Reuters. SARS-CoV2 is the scientific term for the coronavirus that causes COVID-19.
Another leading AstraZeneca executive, Ruud Dobber, had said last month that different strategic options were being explored for AstraZeneca's vaccine operations, which have faced a string of challenges.
APPROVAL TARGETS
The Anglo-Swedish drugmaker has suffered production problems during the rollout of Vaxzevria while very rare cases of blood clotting have weighed heavily on demand for the shot in Europe. The vaccine has also yet to win clearance in the United States.
Concerns over the new Delta variant of COVID-19 and waning vaccine efficacy have prompted several high-income countries to offer a third vaccine shot on top of the usual two-shot regimen to the immunocompromised and other groups at risk.
The immunocompromised, such as those with organ transplants or in cancer care, make up about 2 per cent of the population and would be the main target group for the new therapy. Naval forces on missions could also benefit, among others, Pangalos said.
Even though only 12 per cent to 13 per cent of the trial volunteers were vaccinated when the therapy trial data was generated, AstraZeneca will seek to position the shot as a top-up to previous inoculations.
One or two manufacturing sites at as-yet undisclosed locations would serve world demand, said Pangalos, adding that AstraZeneca stood ready to boost production if countries or international organizations placed bulk orders.
Additional Reporting by Muvija M in Bengaluru; Editing by Sriraj Kalluvila, Jason Neely, David Clarke and Susan Fenton.
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